It’s very easy. There’s a radiator drain upwards in the drivers side on the bottom of the radiator that looks like a large flat head screw to drain the coolant. Only about a gallon to a gallon and a half comes out since these radiators don't hold a lot. Then there's 3x 8mm screws that hold the plastic thermostat housing to the water manifold (T stat is on the lower hose entry to the engine on an Ecoboost which leads to the drivers side). You don't have to even take the large hose off the T stat housing and once the 3x 8mm's are removed you can flex it to the side with no problems since its rubber. The 8mm screw at about the 4pm side on the thermostat housing is a little tough to see but easy to get the 8mm socket onto as well as all the rest. I used a 1/4 inch drive set. When that's pulled, about another quart of coolant will come out with the thermostat and you will see the rubber gasket that slips onto the outside of the thermostat and comes out easily with it. Make sure if you do replace the thermostat that you get the rubber o-ring seal as well since that seals the thermostat and housing.
As far as bleeding, that's very similar to older cars but there's many more hoses and routes it takes so you just need a little more time and top off's. Best way to do that is to try to get the nose of the truck up higher if possible on a hill or floor jack. Only about a half a foot or more is good to get the reservoir as high as possible and all hoses aiming up. Fill the reservoir about an inch over the full line and then slowly squeeze the upper and lower large hoses with the cap still off and bubbles will start to run to the reservoir. Refill to about an inch over the fill line if it fell then install the cap and start the engine and turn the heat in the front and also rear if you have that to full hot. let the car run a few seconds then bring to about 2000 rpm for 30 seconds and then let it idle and while running check the reservoir level. If still over full, let it run until it falls low to re top off or let it get fully hot so the T stat opens if not falling low. If it falls before getting full hot, shut the engine and slowly remove the cap and refill a little over the full line then let it run again. Trick with these is to just keep an eye on them and re top off as the bubbles run to the reservoir if needed but with the nose higher and squeezing the hoses you most likely not even need to top it off. If its over the full line when all done, leave it there and after a few cold starts and hot shut offs it will bleed a little off from the overflow and they usually fall right back to the full line. Overflow in right under the cap behind on the engine side so don't be surprised a few days later to see some drops there.