J, if the unit came out of the same year Expedition as yours, it should be "sort of" plug and play. You will need a navigation antenna that you can mount under the dash. They are on ebay. If you don't have a woofer in your car and the radio came from a car with the woofer, you won't get any low frequency sound from the speakers and they may sound tinny. This didn't bother me for awhile but then I decided to add the woofer. Sirius reception requires the satellite receiver which would be located separately under the very bottom of the console. On bench seat cars, it was located on a bracket under the radio.
Also, if you don't have steering wheel controls, you can add them, but that will require adding pins and wires to the harness. I have an 08 XLT and I put the navigation in mine.
If the unit came from a different model Ford, it may require reprogramming, which several places offer by mail. You'll have to send the radio to them along with about $100 and some information. Improper programming can cause things like lights not working, etc. You can also have it programmed to operate properly without a woofer if you choose not to add one. Adding a woofer would require you to get two plugs and make a five-wire harness between the speaker, radio and fuse box.
Of course, without a microphone mirror and steering wheel switch the voice controls won't work either. You can get an idea of how the radio's programmed by pressing the 3 & 6 hard buttons together and hold them for several seconds while the radio's on and the car's not moving. That opens the "configuration menu" which will tell you if it's programmed for a woofer.
Little by little I added the steering wheel controls and woofer, so the thing works great.
If the unit came from an 07 or 08 the maps are on a DVD that can be replaced, and is sold by Ford for about $150. The $10 bootleg disks fail to work after a few weeks. A command on the menu makes the front fold down ejecting the navigation disk.
Good luck with your project. I had lots of fun with mine and it works and sounds great.