I think dlcorbett summarized issues perfectly. I'll just add that for all the bellyaching about the "complexity" and "unreliability" of the V6 with turbos... Ford has put a ton of these in pickups and SUVs for years, same with the 10 speed now, and if it were any less reliable than average that fact could not have escaped awareness in the market. For me it was one of the reasons I liked the vehicle, you basically get max performance no matter the trim line (Platinum offers what amounts to a different tune, basically). Toyota powertrains are exceptionally reliable but they do that by not innovating (hybrids are the exception). That's a choice you'll pay for at the pump, whether or not it actually saves you money isn't something you'll know for years (as an example).
I think the best thing for the Ford ecoboost engines is to use only synthetic oil and change more frequently than Ford tells you to get away with. So if you buy used, best to be able to verify how well the vehicle was maintained.