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I have 22’s and that tire size from the factory as OE. If they’re an aftermarket wheel, you just have to check the offset (in and out) that could be different but shouldn’t be a problem since the wheel wells are pretty big on these vehicles.
You will be fine with a 285/45r22 on the Expedition if the wheel itself is suited for the truck. I run the same size and a 305/40r23 on mine without an issue
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