We had a 2007 Yukon SLT2 2WD and decided to go with a 2011 Expedition XLT Premium 4WD. Both vehicles have Navigation and a lot of premium features.
My take is this, and of course others will have different opinions.
Yukon strengths over the Expy
1. The Yukon is a quieter ride and a less bumpy ride (2007 2WD vs 2011 4WD at that).
2. The Yukon climate controls are FAR superior to the Expy's. I don't know what Ford engineer was given the green light to have a single button to cycle through having air blow on feet, face, defrost etc, but it's stupid. And you have to press the "auto" button in the Expy to cycle between dual and single climate controls. there is more to talk about here, but ... you get the idea.
3. Our Yukon didn't have bluetooth, but you can get it on the newer ones. And the Yukon has both a "call" and "end call" steerwheel button whereas the Expy has a single button and after pressing it, you have to press a number/button on the nav screen. It's a terrible design on the Expy.
4. The Yukon had a button above the rear view mirror to automatically flip forward the 2nd row, making it easier if you have kids that need to enter the 3rd row.
5. I personally preferred the steering wheel gear shift vs the center mounted shift to save more space for storage in the center console. And the Yukon has steering wheel automatic buttons to shift between gears which is nicer than the old fashioned rugged method of the expy. Both work fine, this was my preference.
6. The yukon felt stronger and easier to accelerate, and seemed to hunt less for the right gear.
7. The yukon has cylinder deactivation which improves gas mileage. I can't say by how much vs the Expy for sure since our Yukon was 2WD vs our 4WD Expy, but a comparable vehicle will get better mileage.
8. The button to close the auto-liftgate on the Yukon is located on the liftgate; it's a better design vs the Expy.
9. The moonroof controls were a little bit nicer. I don't like how on the Expy I have to press the button twice to fully open the moonroof.
10. The factory remote start is built into a single key fob and works like you'd expect, where the engine stays on even if you open a door. On the Expy, you have to troll these forums to figure out how to make that happen. Our factory remote start initially shut off when we opened the door... dumb design.
11. The button for the powerfolding mirrors is more intuitive. And the rain sensing wipers seemed to work better. Our Expy's wipers come on during dry sunny weather for no reason.
12. The Yukon headrests are much better angled for comfort. We almost didn't get an Expy because of how uncomfortable we found the stock headrests.
==== Okay, so by now you are asking, why did I get the Expedition...? ====
Expedition strengths over the yukon
1. You can get cooled seats at a MUCH lower price point. This was a big deal for us being in Dallas and not wanting to spend $63K on a 4WD Yukon Denali.
2. The powerfolding fold-flat 3rd row is MUCH better than the 55lb non-fold-flat Yukon seats that you have to take out of the vehicle to get full storage capacity.
The two points above are why we got an Expedition vs a Yukon.
3. We thought the sync system would be significantly better than the Yukon's nav a/v unit. That said, now that we have it, I'm not convinced. It has some great and unique features, but I have a lot of nits with the design.
4. The expedition's built in garage door opener is MUCH easier to program.
5. Expy's come with two visors over the driver, so you can have one down in front of you and one down on your left side simultaneously.
6. Some Expy's (not ours) 2nd row seats can slide back or forth, and recline signficantly as well.
7. The Expy has a 110 volt plug in the rear (maybe the new Yukons do also, I don't know)
8. The Expy back-up cam has better guidance for distance with lines for yellow/green/red. I know the newer Yukons have the lines, but don't believe they are color coded.