All good advice to a point. If you've been a part of this forum for a while, you'll see the usual diagnostic checks for a misfire. #1, run the diagnostic code checks, #2, run a fuel pressure test, #3 clean out throttle body as bedrck 47 suggested. Your problem is probably a combination of many things. If you get a single coil over plug code, I would pull just that one, test or replace it with either a Ford or Standard brand coil. The cheaper ones from eBay either won't fire proper or burn out quick. You probably should pull and replace with Motorcraft spark plugs. Again they seem to fire the best with these engines. If any of the cylinders have coolant leaking into spark plug area, fix leak immediately. Lastly if you do pull coils, and you probably will, replace all the boots on the coils.
Let us know how it turns out, Moose.
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