im not sure how you came up with the MPG ratings but i think a twin turbo v6 and the diesel would both do far better, at least on the highway mileage.
The Cayenne Turbo S is a 4.8L V8 and does 12/19mpg. so i think it would be safe to say a twin turbo 3.7l v6 SHOULD be able to do like 18-22 mpg city. especially if tuned properly.
HOWEVER i would take ANY mpg had it came with the a twin turbo 6. Ford is supposedly releasing an ecoboost model for every car they sale by 2012...so itd be cool to see them do it to the truck/suv.
should ammend the options for a Twin Turbo V6 tuned for Bio Fuel(E85).
tuners are tuning forced induced cars with E85 because states are banning race fuel for global warming reasons....cali especially. however e85 is super cheap compared to 91 and higher octane plus the e85 has better cooling properties allowing tuners to use more advanced timings and more boost without encountering detonation.
edit:
just realized ford does have an ecoboost f150. now that i think about it, i think its ridiculous that ford just threw the sho motor into a truck. they should have retuned it for the application...that being said, ive always been a turbo guy. only with a turbo can you use a purge valve as a diy boost controller and instantly double your boost...of course fuel needs to be added appropriately, but 450hp shouldnt be hard to extract from the 3.7liter. more efficient exhaust, intake, and a intercooler(not sure if has one equipped) with a boost controller always is good for an additional 100ponies on most turbo vehicles....