It is often not the best for your engine to run but the owner's manual says. Even the manufacturers have often superseded the recommendations for vehicles after they were made. The manufacturer is not concerned with your engine lasting 250,000 miles. They are absolutely not. Their only concern is twofold. Getting out of the warranty. And not feeling considerably sooner than the competition. If all of a sudden all car manufacturers but one had engines that only lasted 80,000 miles, the engine manufacturer that had one that lasted 250 would change their engine and use cheaper materials so it would not last so long. This is simply how the business works.
Even if the manufacturer knows what's best for the engine, which if you believe that you give them too much credit, they often can't recommend the best due to other parameters they have to meet.