I know this thread is a month old, but wanted to chime in with a similar experience. When I first bought my '07 EB, one of the first things I did was clean the engine using the spray on foam engine cleaner. I've used this stuff all my life and never had problems with hosing down an engine occasionally, and taking care to not spray electrical components directly. Boy did I learn how much these 5.4's DON'T like getting wet. Immediately I started having the same symptoms you listed at the beginning of this thread: Misfire under acceleration, engine light coming on, etc etc. After doing some research and figuring out how prone to failure the COP's are, I pulled them all out, blew a bunch of air into each spark plug well, and thoroughly dried out the COPs. Problem solved...there was moisture in one or more of them. The spark plug wells are just holes that want to hold water. You mentioned that you blew a coolant line, I'm betting some of the coolant made it's way into this area.
The COP's on my '07 were really never right after that incident, and I ended up replacing all 8 of them, which made a dramatic difference. Now I just got this 2010, which I promptly replaced the plugs in, and sure enough....it's feeling like the COP's are weak so I'm ordering another set.
Let us know if you fixed your problem with the new plug and COP you mentioned! Thanks