what about me with 160K+ on original fluid? i want to change it, but not sure if i should.
Just drain change filter and fill, and don't forget if you have the 4r100 ( not sure about the 4r70w ) to pull the " rubber plug " from the bottom of the bell housing and turn the motor over until you see the torque converter drain plug and drain it as well ( MAKE SURE TO USE LOCKTITE WHEN YOU PUT THE TORQUE CONVERTER PLUG BACK IN).
AND PLEASE DO NOT USE THE GASKET THAT COMES WITH THE FILTER KIT! These tranny's come from the factory with a REUSABLE METAL CORED GASKET, these gaskets are great and as long as you clean it before reinstall it will not leak. But as you know the rubber gaskets that come with the filter kit, if you tighten even 1 bolt to tight it will

tranny fluid everywhere

.
As long as you replace the fluid with the same type that came out ( if it has never been changed it should be regular Dex/Merc ) and just use a regular tranny fluid like valvoline ( Not the MAXLIFE OR HIGH MILAGE ) because it does not have all of the extra additives that can cause problems then you should be just fine.
Also for the 4r100 ( again not sure about the 4r70w ) Ford has changed the recommended fluid to Mercon V. If it had regular Dex/Merc before you are ok to change to Mercon V, But if it already has had Mercon V THEN MAKE SURE NOT TO FILL IT WITH REGULAR DEX/MERC ( Mercon V is backwards compatible meaning it will mix fine with regular Dex/Merc, but if the tranny had Mercon V before and you try to put in regular Dex/Merc the tranny will get pissed and say

)