JFC, they seem to be having some pretty major issues with these model years.
I think the 4th gens clearly had some issues early on in the run. Mine was one of the first 5,000 off the line, so I think I have had more problems than most. My three "big issues" have been:
1) the 4wd hub actuator failure (which has been fixed on later model years)
2) the cam phaser issue (which is endemic, but not unique to the Expis as it affects F-150s as well)
3) this transmission issue
I have had a couple other small issues (jumpy wing mirrors, massaging seat control not working, etc.) but all of those were small and easily addressed. And all have been remedied on later model years.
I do still have the rattling turbo wastegate, but it's also endemic to all the 3.5 ecoboosts, so not a unique Expi problem. And with the exception of a few folks on here that have had their turbos replaced, I think Ford is basically telling us all to just live with that one.
All that said, I am incredibly happy with my truck overall and wouldn't think of giving it up. I love it. It is a fabulous road trip vehicle, serves our family well, is wildly comfortable, has great power, and looks great.
I have been lucky enough to find an excellent service department and service advisor that always makes a loaner available to me, and they have been really great about working through all my issues quickly. So yes, there have been issues, but I think most are because I was an early adopter and all have been resolved under warranty.
So if you (or anyone else) is scrolling through this forum thinking about buying a 4th gen Expi, my message would be: don't be put off by what you are reading. Most folks don't seek out a forum to tell the world how problem-free their vehicle is; most are on here because they have a problem. So the forum is certainly going to have a high concentration of folks with problems. These really are great vehicles and I would encourage anyone to consider one if they need a big, comfortable, powerful vehicle to haul a bunch of folks and stuff around.