So I just bought a v10 SuperDuty from work for the axles to put under my 'bourbon.
The v10 actually runs well, and am fantasizing about it in my wifelets expy...
A tuned 10, in front of the ZF... hubba hubba...
Possible to stroke this thing to 427/8/9 cid?
Short answer.. No
The V10 and the 5.4 which it is based off (+2 cylinders) already have a long stroke vs bore ratio. (undersquare) 4.16 stoke, 3.55 bore
With out going into a lot of detail this basically limits the available valve size due to the smallish bore thus limiting its ability to breath or feed the available displacement.
Longer stroke is good for torque due to the extra leverage on the crank but most "performance" motors have a bore equal to or bigger than the stroke (oversquare) to improve its ability to breath.
You can overbore about .020 over but this would be insignificant. These are thin wall castings so its generally not recommended to go over that.
There are a lot of other mods you could do with the V10 that would improve performance. Increasing its displacement is not recommended as it would be costly and likely counter productive.