Greetings.
I can't comment on tuners, so I apologize in advance.. but maybe some insight on OBD-II/CAN interfaces will help.
From what you describe, what you will need is a type of device that sits between the OBD-II port and your computer. The device I mention converts signals on the OBD/CAN bus to something that your computer can interpret. This takes care of the hardware requirement. There is a wide variety of hardware that ranges from $20 all the way up to $150+. These devices feature direct, bluetooth, and WiFi connections to the PC or Android Device.
On the computer, you will need some type of software that will communicate with the OBD-II interface mentioned above. There is a wide variety of software packages. Some of them are free from the interface vendor (basic monitoring). Others provide a deep set of parameters which are specific to car manufacturers. Most basic software packages will return information like RPM, simple O2 sensor data, Mass Airflow information, road speed, etc.
Two places on the net are good for getting a baseline of what's out there hardware and software wise.
http://www.scantool.net
http://www.palmerperformance.com
A lot of people like the Centrafuse software for car computers. It not only acts as software I mentioned above, but also gives functionality similar to nav systems. I did not purchase the software when I was building a computer for the car, since I knew eventually I would be getting a new ride. So, here I sit with all the car computer hardware/dash display, scratching my head as to what I'll do with it.
http://www.centrafuse.com/CentrafuseAuto.aspx?pid=93
In my case, I have a bluetooth adapter which plugs into the OBD-II port and connects with my Android Phone. The phone is running software called "Torque" - which gives me the ability to read sensor/ECU data.. and reset the check engine light and read the fault codes ... for those days I had the older F150's. I hope I won't need that any time soon for the '11 !
I hope this gives you a 20,000 high view of OBD-II, interfaces, and software out there.