As for mods to improve mileage, I have done quite a few. Some may say that some would hurt, but it is all in how you do them:
-Gotts mod to open up the air box and using a K&N filter
-e-fan conversion set up on separate controllers, offset by about 10F at 195 and 205F
-true dual exhaust using 2.5" piping and a 70 series muffler
-port/polish of intake to allow for easier movement of air by the engine
-run the tires at the higher end of the pressure band while still maintaining an even tread pressure on the ground
-keeping the engine RPMs between 1800-2200 RPM when at a steady speed (works out to be about 60-72 mph)
-when accelerating, depressing the accelerator so the engine RPMs come up to about 2,500 and then the engine shifts without me moving my foot
-when approaching a red light, let off the gas as early as possible to allow the truck to coast as long as possible.
The last few are more driving style things than actual "mods" to the truck. But, every little bit helps. The only modification that I can think of that I could do to make things better would be to drop the truck, go back to the stock 255's and build a dam on the front of the truck to minimize the amount of air going under the truck. But, with how Nukie is, that is just not going to happen.