Honestly, I love my 22's. The wider tires (305) and the lower profiles (40) help the truck so much in terms of handling. Handling is unbelievably better. It tracks better on the highway and obviously taking turns is much better. The ride is stiffer and more responsive, but with 40 series tires, there is plenty of sidewall and it absorbs the road conditions comparably to a car. A 45 series would be even better for comfort, though. It's easier to find all season tires in 45 series, too. Only downsides would be the cost, changing tires with the seasons (if you don't get all season tires), speedo/odo inaccuracy, and slightly reduced braking. All in all, though, I love them and they are the best investment I made in my ride.