I hadn't bothered to check for profiles on the Sync 4 screen, but keep in mind that driver numbers associated with the button on the door or the keyfob that you've matched still apply, and most of the settings in the Sync 4 screen apply. This screwed me up yesterday when I forced the running boards to stay deployed in order to go through the carwash. Except, I applied my driver number after making the change, so, of course, my running boards were in auto during the carwash, and didn't get cleaned.
I never actually use the feature of my Mach E, but I think the same thing applies. I just hit the door button to switch to my profile after my wife uses the car. I think PaaK is supposed to do this automatically, though, so maybe that's broken.
On the expedition the door number recalls the seat and wheel settings. Not the sync 4 settings.
I.e. my wife is #2, if she presses it my radio presets are still there.