the entire concept behind boost outside of performance circles is "on demand" or "when you need it".
if a 5.0 engine had 100% VE, it's displacing that 5.0L every full cycle of the engine. it's not a partial pump. it achieves it's power through adding RPM's and air, and catalyst (fuel) accordingly. it has a fraction of the moving parts compared to a boosted engine, and especially lacking the high RPM's of a turbo, where balance has to be perfect and seals and bearing always replenishing their lubricity. so... yeah. boosted application have points of failure n/a's don't have.
however.... a 2.5L engine, if it also enjoyed 100% VE, and equipped with boost capable of one atmosphere (14.7#'s at sea level) and reaching that boost is now pumping the same VE as the 5.0 mentioned above... precisely the same... and using the same volume of catalyst (fuel) to do so.... creating the same power.... but it DOESN'T when boost isn't demanded. when boost is idle (at 0psi) it burns fuel required for a 2.5L engine, not a 5.0L engine. on demand. when needed.
I watch my boost on my 6.4PSD closely- i only run it hard enough to achieve the goal- no racing around in a 12k# pickup, though it will hit 60 in right at five seconds and a 1/4 in high 12's low 13's. off the line boost is near 25# even on low/moderate acceleration... on the highway? it holds about 8~10#'s. it's not needed.
n/a gassers built to provide towing power for a 10k load, if not geared properly, expend their available energy off the line- and the rest is wasted once inertia is established, and because it takes a fraction of power to keep something going as it does to get it there. that means you're burning excess fuel after it's rolling. boosted applications don't have this problem.
a boosted application of the same displacement and VE as a n/a application is done for performance purposes... you can fit a small block in a mustang, let's say, where a big block won't fit. boosting allows performance of the big block in a space the big block can't fit. hella more power to footprint and weight ratio...
boost is the direction of the future where internal combustion is concerned. the biggest reason all engines and vehicles aren't equipped with it is the OE investment in tools, casts, and dies- and the added expense of additional parts. that's it.