2nd Gen Ecoboost engines have both port injectors and direct injectors
The direct injectors inject fuel directly into the cylinder, the fuel never "washes" the outside of the intake valve.
Port injection happens further back in the air stream before the intake valve so a mixture of air, egr gases and fuel travels over the back of the intake valve during the intake stroke. This help clean the crud* that can build up on the back of the valve. This crud bakes on (from memory) mostly from 180C to 290c which coincidentally is the exact range an intake valve with just air passing over it sits at a lot of the time
So now that we have port injection, the cleaners in a top tier fuel can do their thing or even dumping a bottle of fuel cleaner works. Pure direct injection engines (Gasoline Direct Injection - GDI) don't have an ability to do this and spraying cleaner directly into the air stream to remove baked on sludge is marginally effective and in the closely coupled turbos on the Ecoboost, is likeley to destroy them due to overheat as the unburnt cleaner ignites exiting the exhaust port, down the manifold and into your turbo. According to Ford anyway.
*crud = oily gases from EGR system that deposit on the valve, get baked on just like grease on a baking tin in your oven and forms a hard carbon type material that can lead to improperly seating valves and possibly damaged valve stem oil seals.